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Antioxidants and Cancer

Preventing cancer and heart disease -- do antioxidants help?

Epidemiologic observations show lower cancer rates in people whose diets are rich in fruits and vegetables. This has lead to the theory that these diets contain substances, possibly antioxidants, which protect against the development of cancer. There is currently intense scientific investigation into this topic. Thus far, none of the large, well designed studies have shown that dietary supplementation with extra antioxidants like acai berries reduces the risk of developing cancer. In fact one study demonstrated an increased risk of lung cancer in male smokers who took antioxidants vs. male smoker who did not supplement. Whether this effect was from the antioxidants is unknown but it does raise the issue that antioxidants may be harmful under certain conditions.

Antioxidants are also thought to have a role in slowing the aging process and preventing heart disease and strokes. Perhaps the best advice, which comes from several authorities in cancer prevention, is to eat 5 servings of fruit like blueberries or vegetables per day. One of the more popular fruits with a very high anti oxidant rating and the highest ORAC rating of any fruit is the goji berry , also called wolf berry.

Exercise and oxidative damage

Endurance exercise can increase oxygen utilization from 10 to 20 times over the resting state. This greatly increases the generation of free radicals, prompting concern about enhanced damage to muscles and other tissues. The question that arises is, how effectively can athletes defend against the increased free radicals resulting from exercise? Do athletes need to take extra antioxidants?

Because it is not possible to directly measure free radicals in the body, scientists have approached this question by measuring the by-products that result from free radical reactions. If the generation of free radicals exceeds the antioxidant defenses then one would expect to see more of these by-products. These measurements have been performed in athletes under a variety of conditions.

Several interesting concepts have emerged from these types of experimental studies. Regular physical exercise enhances the antioxidant defense system and protects against exercise induced free radical damage. This is an important finding because it shows how smart the body is about adapting to the demands of exercise. These changes occur slowly over time and appear to parallel other adaptations to exercise.

On the other hand, intense exercise in untrained individuals overwhelms defenses resulting in increased free radical damage. Thus, the "weekend warrior" who is predominantly sedentary during the week but engages in vigorous bouts of exercise during the weekend may be doing more harm than good. To this end there are many factors which may determine whether exercise induced free radical damage occurs, including degree of conditioning of the athlete, intensity of exercise, and diet.

 

Can antioxidant supplements prevent exercise induced damage or enhance recovery from exercise?

Although it is well known that vitamin deficiencies can create difficulties in training and recovery, the role of antioxidant supplementation in a well nourished athlete is controversial. The experimental studies are often conflicting and conclusions are difficult to reach. Nevertheless, most of the data suggest that increased intake of vitamin E is protective against exercise induced oxidative damage. It is hypothesized that vitamin E is also involved in the recovery process following exercise. Currently, the amount of vitamin E needed to produce these effects is unknown. The diet may supply enough vitamin E in most athletes, but some may require supplementation. There is no firm data to support the use of increased amounts of the other antioxidants.

Performance

In general, antioxidant supplements have not been shown to be useful as performance enhancers. The one exception to this is vitamin E which has been shown to be useful in athletes exercising at high altitudes. A placebo controlled study done on mountaineers demonstrated less free radical damage and decline in anaerobic threshold in those athletes supplemented with vitamin E. Although difficult to generalize, this finding suggests that supplementation with vitamin E might be beneficial in those triathletes who are adapting to higher elevations.

How much is enough?

Although there is little doubt that antioxidants are a necessary component for good health, no one knows if supplements should be taken and, if so, how much. Antioxidants supplements were once thought to be harmless but increasingly we are becoming aware of interactions and potential toxicity. It is interesting to note that, in the normal concentrations found in the body, vitamin C and beta-carotene are antioxidants; but at higher concentrations they are pro-oxidants and, thus, harmful. Also, very little is known about the long term consequences of megadoses of antioxidants. The body's finely tuned mechanisms are carefully balanced to withstand a variety of insults. Taking chemicals without a complete understanding of all of their effects may disrupt this balance.

Recommendations

  • Follow a balanced training program that emphasizes regular exercise and eat 5 servings of fruit or vegetables per day. This will ensure that you are developing your inherent antioxidant systems and that your diet is providing the necessary components.

  • Weekend warriors should strongly consider a more balanced approach to exercise. Failing that, consider supplementation.

  • For extremely demanding races (such as an ultradistance event), or when adapting to high altitude, consider taking a vitamin E supplement (100 to 200 IU, approximately 10 times the RDA) per day for several weeks up to and following the race.

  • Look for upcoming FDA recommendations, but be wary of advertising and media hype.

  • Do not oversupplement.

Selected References

  1. The Effect of Vitamin E and Beta Carotene on the Incidence of Lung Cancer and Other Cancers in Male Smokers New England Journal of Medicine (NEJM). vol 330 (15) Apr. 14, 1994. pp 1029-1035.

  2. A Clinical Trial of Antioxidant Vitamins to Prevent Colorectal Adenoma NEJM, vol 331 (3). July 21, 1994. pp 141-147

  3. Antioxidant Vitamins -- Benefits Not Yet Proved (editorial) NEJM vol 330 (15) Apr. 14, 1994. p 1080 - 1081

  4. Antioxidants and Physical Performance (review) Critical Reviews in Food Science and Anti Aging Super Food, 35(1&2):131-141 (1995).

  5. Increased blood antioxidant systems of runners in response to training load. Clinical Science (1991). 80, 611-618.

  6. Exercise, Oxidative Damage and Effects of Antioxidant Manipulation (review). Journal of Anti Aging Super Food 122(3 suppl): 766-73, 1992 Mar.

  7. Antioxidants: role of supplementation to prevent exercise-induced oxidative stress (review). Medicine and Science in Sports and Exercise. 25(2):232-6, 1993 Feb.

  8. Prospects for the use of antioxidant therapies.(Review). Drugs 49(3):345-61, 1995 Mar.

In accordance with the FDA these products are not intended to treat, cure, mitigate, or prevent any diseases. Please consult your health care professional prior to taking dietary supplements. Information on this site is given for educational purposes only and is not to replace the advice of your doctor. If you have a health condition, please seek the advice of your doctor.

 

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Information in this document is subject to change without notice.
Last modified: March 22, 2011